Description
Spedra 50mg contains avanafil, a PDE5 inhibitor used to treat erectile dysfunction (ED). It works by increasing blood flow to the penis—sexual stimulation is still required for an erection. This strength is suitable when a clinician has recommended a lower starting dose or when you prefer a milder option.
What is Spedra 50mg and how does it work?
Spedra (avanafil) helps men with ED achieve and maintain an erection by relaxing blood vessels in the penis. Compared to some alternatives, avanafil is known for its fast onset. Food does not stop Spedra from working, but a large, high‑fat meal may delay the effect.
Who can take Spedra 50mg?
Adults with ED who have been assessed as suitable during an online consultation or by their prescriber. Tell your clinician about your medical history and medicines before use.
Directions for use
Dosage
Take one 50mg tablet 15–30 minutes before sexual activity. Do not take more than once per day. Your prescriber may adjust the dose based on effectiveness and tolerability.
How to take
Swallow the tablet whole with water. You can take it with or without food, but heavy or high‑fat meals may delay onset. Limit alcohol as it may reduce efficacy and increase side effects.
Precautions
Sexual stimulation is required for Spedra to work. Do not exceed the prescribed dose. If you experience dizziness or vision changes, do not drive or operate machinery.
Onset & duration
Spedra 50mg may start working within 15–30 minutes and can last for approximately 4–6 hours. Individual response varies.
Side effects
Common
Headache, flushing, nasal congestion, and indigestion are among the most commonly reported effects.
Serious—seek urgent help
Stop taking Spedra and seek immediate medical attention if you experience chest pain, sudden vision or hearing loss, or an erection lasting longer than 4 hours (priapism).
Interactions & when to avoid
Do NOT take Spedra if you use nitrate medicines (for chest pain) or riociguat, as this combination can cause dangerous drops in blood pressure. Use caution with alpha‑blockers (risk of low blood pressure) and tell your clinician if you take strong CYP3A4 inhibitors or inducers. Avoid excessive alcohol.
Ingredients
Active ingredient
Avanafil 50mg per tablet.
Excipients
See the patient information leaflet for the full list of excipients.
Why buy from us
- GPhC‑regulated UK online pharmacy
• Free online GP consultation
• Discreet, tracked next‑day delivery options
• Pharmacist support and aftercare
Spedra vs other ED tablets (quick view)
- Spedra (avanafil): Onset ~15–30 min; duration ~4–6h; large meals may delay onset.
• Sildenafil (Viagra): Onset ~30–60 min; duration ~4–5h; food—especially fat—can delay onset.
• Tadalafil (Cialis): Onset ~30–60 min; duration up to 36h; less affected by food.
FAQs
How quickly does Spedra 50mg work?
Usually within 15–30 minutes with sexual stimulation.
How long does it last?
About 4–6 hours, depending on the individual.
Do I need a prescription?
Yes. Complete our free online consultation to obtain one.
Is it suitable for everyone?
Not for people taking nitrates or riociguat and those with certain medical conditions. Use only as advised by a clinician.

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