Description
Panadol Night Tablets are expertly designed to relieve pain that prevents a good night’s sleep. Each film-coated tablet contains 500 mg paracetamol to relieve mild-to-moderate pain and reduce fever, paired with 25 mg diphenhydramine hydrochloride, a sedating antihistamine to aid sleepiness and reduce night-time awakening .
A reliable choice for bedtime discomfort including:
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Headache and migraine
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Backache, rheumatic, and muscular pain
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Toothache and neuralgia
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Period pain
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Sore throat, cold symptoms, and fever
These caplets help you fall and stay asleep by reducing pain and inducing mild sedation—without morning grogginess.
Instructions for Use
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Adults & adolescents (16+): Take 2 tablets with water about 20 minutes before bedtime.
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Max 2 tablets per night, no more than 7 consecutive nights without consulting a doctor.
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Keep at least 4 hours between any daytime paracetamol doses—limit daytime paracetamol to a maximum of 6 tablets in 24 hours.
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Not suitable for children under 16, pregnant or breastfeeding women, or those taking other sedatives.
Warnings & Precautions
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Don’t combine with other paracetamol or antihistamine medications due to risk of serious side effects .
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Avoid alcohol and driving/machinery — tablet induces drowsiness Consult a GP/pharmacist before use if you have:
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Liver or kidney disease, epilepsy, asthma, COPD, prostate issues, glaucoma, or urinary retention
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Use of MAO inhibitors, SSRIs, codeine, sedatives, or other antimuscarinic drugs
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Not for use in elderly with confusion or sedation due to risk of paradoxical excitation.
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Stop and seek immediate medical attention if pain persists beyond 7 nights or symptoms escalate.
Side Effects
Common:
Drowsiness, sedation, dizziness, tiredness, dry mouth, blurred vision, unsteady gait .
Rare/serious:
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Allergic reactions (rash, swelling, breathing issues)
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Difficulty urinating, confusion, rapid heartbeat, seizures, metabolic acidosis, breathing problems
Discontinue immediately and seek medical help if unusual or severe side effects occur. Report via MHRA Yellow Card Scheme.
Pack & Ingredients
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Contains 20 film-coated caplets.
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Active: Paracetamol 500 mg + Diphenhydramine HCl 25 mg per tablet.
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Excipients include maize starch, lactose, hypromellose, preservatives, colourings (E133, E132).
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Contains lactose; not suitable for patients with lactose intolerance
Storage & Handling
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Store in a cool, dry place below 25 °C, out of reach of children .
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Keep caplets in original pack until use.
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Do not use after the expiry date printed.
Why Buy from MedCare Pharmacy?
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Fully UK-regulated pharmacy with licensed pharmacists
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Discreet, fast UK delivery with free options on qualifying orders
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Pharmacist support included with each order
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Trusted by thousands of UK customers

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