Description
Malarone 250mg / 100mg Tablets are a prescription antimalarial medicine used for both malaria prevention and treatment, particularly against chloroquine-resistant Plasmodium falciparum. Each tablet contains Atovaquone 250mg and Proguanil hydrochloride 100mg, providing dual-action protection for travellers visiting high-risk regions. Buy Malarone online in the UK following a confidential travel health consultation with a UK-registered prescriber.
What Is Malarone 250mg / 100mg?
Malarone combines two antimalarial agents that work at different stages of the parasite lifecycle. It is widely recommended by NHS Fit for Travel and TravelHealthPro for malaria prophylaxis and treatment.
How Malarone Works
Atovaquone Mechanism
Atovaquone blocks mitochondrial electron transport in the malaria parasite, disrupting energy production inside infected red blood cells.
Proguanil Mechanism
Proguanil inhibits folate synthesis, preventing parasite DNA replication and multiplication.
What Is Malarone Used For?
Malaria Prevention (Prophylaxis)
Adults: Take one tablet daily starting 1–2 days before entering a malaria-risk area. Continue daily during travel and for 7 days after leaving the region. Take with food or a milky drink for optimal absorption.
Malaria Treatment
Adults: Take four tablets once daily for three consecutive days, as prescribed by your clinician.
Key Benefits of Malarone
- Effective against chloroquine-resistant strains
• Suitable for short-notice travel
• Short 7-day post-travel continuation period
• Dual-action combination therapy
• Trusted UK travel medicine option
Ingredients
Active ingredients: Atovaquone 250mg and Proguanil hydrochloride 100mg.
Inactive ingredients include microcrystalline cellulose, low-substituted hydroxypropyl cellulose, poloxamer 188, magnesium stearate, hypromellose, and titanium dioxide.
Possible Side Effects
Common Effects
Headache, nausea, vomiting, stomach pain, diarrhoea, dizziness.
Serious Reactions
Allergic reactions (facial swelling, rash), severe dizziness, persistent vomiting. Seek medical attention if severe symptoms occur.
Precautions and Warnings
Not recommended during pregnancy or breastfeeding unless no safer alternative exists. Take with food or milk. Inform your clinician if you have kidney or liver impairment. Complete the full course including 7 days after travel.
Frequently Asked Questions
- When should I start taking Malarone?
Start 1–2 days before entering a malaria-risk region. - How long should I continue after travel?
Continue daily for 7 days after leaving the region. - Can Malarone treat malaria infection?
Yes, it is licensed for both prevention and treatment. - What happens if I miss a dose?
Take it as soon as remembered unless near the next dose. Do not double dose. - Why must I take Malarone with food?
Food improves absorption and effectiveness. - Is Malarone effective against resistant malaria?
Yes, particularly chloroquine-resistant Plasmodium falciparum. - Can I drink alcohol while taking Malarone?
Moderate alcohol is allowed but may worsen nausea or dizziness. - Is Malarone safe during pregnancy?
Generally avoided unless advised by a clinician. - Can children take Malarone?
Suitable for adults and children over 40kg unless otherwise prescribed. - What are warning signs requiring urgent care?
Allergic reactions, persistent vomiting, severe dizziness. - Do I need a prescription in the UK?
Yes, Malarone 250mg/100mg requires medical assessment before supply.

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