Description
Lariam (Mefloquine) 250mg Tablets are a prescription antimalarial medicine used for the prevention and treatment of malaria, including infections caused by chloroquine-resistant Plasmodium falciparum. Buy Lariam 250mg online in the UK following a confidential travel health consultation with a UK-registered prescriber. Fast and discreet UK delivery available.
What Is Lariam (Mefloquine) 250mg?
Lariam contains Mefloquine hydrochloride 250mg. It works during the erythrocytic (red blood cell) stage of the malaria parasite lifecycle, inhibiting replication and survival. It is effective against multiple Plasmodium species including P. falciparum and P. vivax.
What Is Lariam Used For?
Malaria Prevention (Prophylaxis)
Adults and children over 45kg: 1 tablet once weekly. Start 2–3 weeks before travel to malaria-endemic areas, continue weekly during travel, and for 4 weeks after leaving the risk area.
Malaria Treatment
Adults and children over 45kg: 5 tablets (1250mg) as a single dose, sometimes divided to reduce side effects, as prescribed by a clinician.
Why Lariam Is Recommended
- Weekly dosing convenience
• Effective against resistant P. falciparum strains
• Suitable for both prevention and treatment
• Referenced by WHO and NHS Fit for Travel guidance
• Suitable for long-term travellers and expatriates in endemic regions
Ingredients
Active ingredient: Mefloquine hydrochloride 250mg.
Inactive ingredients: Microcrystalline cellulose, Maize starch, Poloxamer, Lactose monohydrate, Magnesium stearate.
Possible Side Effects
Common Effects
Nausea, vomiting, dizziness, vertigo, headache, disturbed sleep including vivid dreams or insomnia.
Rare but Serious Reactions
Mood changes, anxiety, hallucinations, or other neuropsychiatric symptoms. Stop use and seek immediate medical advice if severe symptoms occur.
Precautions and Warnings
Not recommended during the first trimester of pregnancy unless no safer alternative is available. Avoid if you have a history of depression, anxiety disorders, or seizure conditions. Always take with food and water. Continue for 4 weeks after leaving the malaria-risk region.
Frequently Asked Questions
- When should I start taking Lariam?
Start 2–3 weeks before entering a malaria-endemic region. - How long should I continue after travel?
Continue weekly for 4 weeks after leaving the risk area. - Is Lariam effective against resistant malaria?
Yes, it is effective against chloroquine-resistant P. falciparum. - Can Lariam treat malaria as well as prevent it?
Yes, it is licensed for both treatment and prophylaxis. - What if I miss a weekly dose?
Take it as soon as remembered unless your next dose is due within 24 hours. - Can Lariam cause mental health side effects?
Yes, neuropsychiatric effects can occur in rare cases. - Is Lariam safe during pregnancy?
Consult your clinician, particularly during early pregnancy. - Should I combine Lariam with mosquito precautions?
Yes, always use insect repellent and protective clothing. - Why must I start 2–3 weeks before travel?
This allows blood levels to stabilise before exposure. - Can children take Lariam?
Yes, dosage is weight-based and requires medical guidance. - Do I need a prescription in the UK?
Yes, Lariam 250mg requires medical assessment before supply.

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