Description
Atovaquone and Proguanil 250mg/100mg Tablets are a prescription antimalarial medicine used for both prevention (prophylaxis) and treatment of malaria. This dual-action combination is effective against chloroquine-resistant Plasmodium falciparum and is widely prescribed for travellers visiting malaria-endemic regions in Africa, Asia, and South America. Buy Atovaquone and Proguanil online in the UK following a confidential travel health assessment.
What Is Atovaquone and Proguanil?
This medicine combines Atovaquone 250mg and Proguanil hydrochloride 100mg in a single tablet. It works at different stages of the malaria parasite lifecycle to prevent infection and eliminate parasites already present in the bloodstream.
How Atovaquone and Proguanil Works
Atovaquone Mechanism
Atovaquone inhibits mitochondrial electron transport within the malaria parasite, blocking energy production inside infected red blood cells.
Proguanil Mechanism
Proguanil interferes with parasite DNA synthesis in the liver stage, helping prevent progression and relapse.
What Is It Used For?
Malaria Prevention (Prophylaxis)
Take one tablet daily with food or a milky drink. Begin 1-2 days before entering a malaria-risk area, continue daily during travel, and for 7 days after leaving the region.
Malaria Treatment
For treatment, take four tablets once daily for three consecutive days, always with food or a milky drink, as directed by your clinician.
Key Benefits
- Effective against chloroquine-resistant strains
• Suitable for prevention and treatment
• Convenient once-daily dosing for prophylaxis
• Short post-travel continuation period (7 days)
• Trusted by UK travel health clinics
Ingredients
Active ingredients: Atovaquone 250mg and Proguanil hydrochloride 100mg.
Inactive ingredients include microcrystalline cellulose, hydroxypropyl cellulose, sodium starch glycolate, magnesium stearate, hypromellose, and titanium dioxide.
Possible Side Effects
Common Effects
Nausea, vomiting, abdominal pain, diarrhoea, headache.
Less Common Effects
Mouth ulcers, skin rashes, abnormal liver function tests.
Warnings and Precautions
Always take with food or milk to improve absorption. Not recommended for children under 40kg unless prescribed. Consult your clinician if you have kidney or liver impairment. Continue protection for 7 days after leaving a malaria-endemic area.
Frequently Asked Questions
- When should I start taking Atovaquone and Proguanil?
Start 1–2 days before entering a malaria-risk area. - How long do I continue after travel?
Continue daily for 7 days after leaving the malaria region. - Can it treat malaria as well as prevent it?
Yes, it is licensed for both prevention and treatment. - Why must I take it with food?
Food improves absorption and effectiveness. - What if I miss a dose?
Take as soon as remembered unless close to the next dose. Do not double dose. - Is it effective against resistant malaria?
Yes, it works against chloroquine-resistant Plasmodium falciparum. - Can I drink alcohol while taking it?
Moderate alcohol is not directly contraindicated, but dehydration should be avoided. - Is it suitable for children?
Not recommended under 40kg unless specifically prescribed. - Can I stop early if I feel well?
No, complete the full course including the 7-day post-travel period. - What are warning signs requiring medical help?
Persistent vomiting, severe abdominal pain, or allergic reactions require medical attention. - Do I need a prescription in the UK?
Yes, this medicine requires a prescription following travel assessment.

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