How Effective is Amycretin for Weight Loss?
Amycretin is rapidly emerging as one of the most promising new weight loss medications on the horizon. Developed by Novo Nordisk, this next-generation weight loss drug acts as a dual agonist for both GLP-1 and amylin receptors. Early research shows it could rival or even outperform existing treatments like Mounjaro and Wegovy.
In clinical trials, patients taking Amycretin 20mg experienced an average 22% weight loss over just 36 weeks. These results are especially striking when compared to the leading competitors in the weight loss injection space.
How Does Amycretin Compare to Other Weight Loss Medications?
To understand how effective Amycretin is, it’s useful to see how it stacks up against other well-known weight loss treatments:
- Wegovy: ~13% weight loss at 36 weeks; 14.9% at 68 weeks
- Mounjaro (tirzepatide): 25.3% average weight loss at 88 weeks
- Orlistat (Orlos): ~40% of users lose at least 10% over 52 weeks
While Amycretin’s results don’t yet span a full year, the early data indicates a faster and more substantial drop in weight than many alternatives making it a serious contender in future obesity treatment protocols.
How Amycretin Works in the Body
Amycretin mimics two powerful hormones GLP-1 and amylin that regulate appetite and fullness. While other medications like Wegovy and Saxenda target GLP-1 alone, and Mounjaro targets GLP-1 and GIP, Amycretin uniquely combines GLP-1 and amylin activity.
- GLP-1 slows gastric emptying, regulates blood sugar, and reduces hunger.
- Amylin signals satiety directly to the brain, helping users feel fuller faster.
This dual-action mechanism is thought to enhance weight loss effectiveness and potentially reduce the likelihood of gastrointestinal side effects.
🔹 Side Effects of Amycretin vs Other Options
Like most GLP-1 based treatments, Amycretin does come with some side effects. These are mostly related to digestion, particularly during the initial treatment phase or when the dosage is increased too quickly.
Reported side effects include:
- Nausea
- Vomiting
- Diarrhoea
- Constipation
- Fatigue
- Headaches
However, since amylin acts on the brain rather than the gut, there’s early speculation that Amycretin might trigger fewer stomach-related issues than drugs like Wegovy or Saxenda. Still, more clinical data is needed to confirm this advantage.
Side Effects Compared to Placebo:
- Nausea: 11% (vs. placebo)
- Fatigue: 9%
- Diarrhoea: 8%
- Headache: 6%
- Vomiting: 5%
In contrast, Orlistat has a very different side effect profile, including:
- Oily stools
- Urgent bowel movements
- Abdominal cramps
These can be disruptive for many users, making GLP-1 treatments a more attractive option.
Long-Term Effectiveness: What We Still Don’t Know
While early results for Amycretin are extremely promising, there’s still a lot we don’t yet know:
- Will weight loss plateau after a certain point?
- Can patients maintain weight loss long-term?
- What’s the optimal dose for sustained results?
Since trials haven’t yet passed the 52-week or 88-week benchmarks, we’re still waiting on comprehensive long-term data. But current figures suggest that Amycretin could become one of the most effective weight loss treatments ever developed.
🔹 When Will Amycretin Be Available in the UK?
Amycretin is still in clinical trial stages and has not yet received regulatory approval. However, Novo Nordisk has stated that they anticipate the medication will be ready for launch soon.
Until then, patients in the UK can access a range of proven GLP-1 medications such as Mounjaro, Wegovy, and Saxenda, which are available via private prescription through MedCare Health Clinic.
The Bottom Line
Amycretin represents a major step forward in medical weight loss treatments. With its unique dual mechanism and impressive trial data, it may soon become the preferred choice for those seeking effective, science-backed weight management options.
While we’re still awaiting long-term results, Amycretin’s potential to reshape obesity treatment is clear.
MedCare Health Clinic will be among the first UK providers offering private consultations and prescriptions for Amycretin once it becomes available. Stay ahead of the curve join our interest list or speak to one of our clinicians about your weight loss options today.